线粒体功能缺乏在多种神经系统疾病中上演要道变装。在蛛网膜下腔出血中，缺血缺氧导致线粒体功能受损，开释大皆活性氧和炎症介质，激活凋一火通路，而线粒体质料甩掉机制是潜在调节靶点。在亨廷顿病中，CAG访佛扩增导致线粒体能量代谢缺乏、生物发生相称、运载受阻及钙稳态失调。脊髓毁伤后，线粒体稳态碎裂影响ATP产生，结巴轴突再生与成就，世界杯官网规复线粒体功能可促进神经功能规复。在阿尔茨海默病中，线粒体功能缺乏与脑葡萄糖代谢裁汰密切有关，葡萄糖缺少导致O-GlcNAcylation水平改动，进而影响线粒体功能。
线粒体聚积能源学曲折、氧化磷酸化相称及活性氧过度产生是这些疾病的共同病理机制，针对线粒体生物发生、能源学均衡、运载功能及代谢相称的搅扰战略为神经系统疾病调节提供了新主义。
因此，特精选本刊2023-2024年发表的线粒体功能缺乏在神经系统疾病中的作用征询的热门综述著述5篇，供读者参阅。
(1) Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage
线粒体功能缺乏和质料甩掉是蛛网膜下腔出血的中枢场所
张开剩余82%援用本文：
Zhang J， Zhu Q， Wang J， Peng Z， Zhuang Z， Hang C， Li W. Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage. Neural Regen Res. 2024;19(4):825-832.
正文不时:
https://journals.lww.com/nrronline/fulltext/2024/04000/mitochondrial_dysfunction_and_quality_control_lie.27.aspx
{jz:field.toptypename/}(2) Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions
线粒体基因突变与脑部疾病之间的交叉关联：线粒体靶向调节搅扰的真理
援用本文：
Kalra J. Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions. Neural Regen Res. 2023;18(1):94-101.
正文不时:
https://journals.lww.com/nrronline/fulltext/2023/01000/crosslink_between_mutations_in_mitochondrial_genes.14.aspx
(3) Mitochondria in Huntington's disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies
亨廷顿氏病中的线粒体：对发病机制和线粒体靶向调节战略的影响
援用本文：
Jurcau A， Jurcau CM. Mitochondria in Huntington's disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies. Neural Regen Res. 2023;18(7):1472-1477.
正文不时:
https://journals.lww.com/nrronline/fulltext/2023/07000/mitochondria_in_huntington_s_disease__implications.12.aspx
(4) Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches
脊髓毁伤中线粒体功能缺乏行为靶点：病理经过与调节战略的密切关联
援用本文：
Schmidt J， Quintá HR. Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches. Neural Regen Res. 2023;18(10):2161-2166.
正文不时:
https://journals.lww.com/nrronline/fulltext/2023/10000/mitochondrial_dysfunction_as_a_target_in_spinal.10.aspx
(5) Altered O-GlcNAcylation and mitochondrial dysfunction， a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease
O-GlcNAcylation改动与线粒体功能缺乏——脑葡萄糖调理失常与散漫性阿尔茨海默病间的分子关联
援用本文：
Huang CW， Rust NC， Wu HF， Hart GW. Altered O-GlcNAcylation and mitochondrial dysfunction， a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease. Neural Regen Res. 2023;18(4):779-783.
正文不时:
https://journals.lww.com/nrronline/fulltext/2023/04000/altered_o_glcnacylation_and_mitochondrial.14.aspx
发布于：辽宁省
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